Ontology highlight
ABSTRACT:
SUBMITTER: Cherniack AD
PROVIDER: S-EPMC5599133 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Cancer cell 20170301 3
We performed genomic, epigenomic, transcriptomic, and proteomic characterizations of uterine carcinosarcomas (UCSs). Cohort samples had extensive copy-number alterations and highly recurrent somatic mutations. Frequent mutations were found in TP53, PTEN, PIK3CA, PPP2R1A, FBXW7, and KRAS, similar to endometrioid and serous uterine carcinomas. Transcriptome sequencing identified a strong epithelial-to-mesenchymal transition (EMT) gene signature in a subset of cases that was attributable to epigene ...[more]