Both antenatal and postnatal inflammation contribute information about the risk of brain damage in extremely preterm newborns.

ABSTRACT: BackgroundPreterm newborns exposed to intrauterine inflammation are at an increased risk of neurodevelopmental disorders. We hypothesized that adverse outcomes are more strongly associated with a combination of antenatal and postnatal inflammation than with either of them alone.MethodsWe defined antenatal inflammation as histologic inflammation in the placenta. We measured the concentrations of seven inflammation-related proteins in blood obtained on postnatal days 1, 7, and 14 from 763 infants born before 28 weeks of gestation. We defined postnatal inflammation as a protein concentration in the highest quartile on at least 2 days. We used logistic regression models to evaluate the contribution of antenatal and postnatal inflammation to the risk of neurodevelopmental disorders.ResultsThe r

SUBMITTER: Yanni D 

PROVIDER: S-EPMC5599336 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature