Revisiting the role of the insula and smoking cue-reactivity in relapse: A replication and extension of neuroimaging findings.

ABSTRACT:

Introduction

The ability to direct smoking cessation treatment based on neuroscientific findings holds incredible promise. However, there is a strong need for consistency across studies to confirm neurobiological targets. While our prior work implicated enhanced insula reactivity to smoking cues in tobacco smoking relapse vulnerability, this finding has not been confirmed.

Method

Using functional magnetic resonance imaging (fMRI), we evaluated the pre-cessation brain reactivity to smoking vs. neutral cues in nicotine dependent smokers who were and were not able to maintain subsequent abstinence.

Results

Of the 23 (7 women) individuals assessed, 13 relapsed and there were no demographic differences between those who did and did not relapse. However, smokers who relapse

SUBMITTER: Janes AC 

PROVIDER: S-EPMC5599349 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature