Sex differences in guanfacine effects on stress-induced stroop performance in cocaine dependence.

ABSTRACT:

Aims

Chronic drug abuse leads to sex-specific changes in drug cue and stress physiologic and neuroendocrine reactivity as well as in neural responses to stress and cue-related challenges and in executive function such as inhibitory control, cognitive flexibility and self control. Importantly, these functions have been associated with high risk of relapse and treatment. Alpha-2 agonism may enhance inhibitory cognitive processes in the face of stress with sex-specific effects, however this has not been previously assessed in cocaine dependence.

Method

Forty inpatient treatment-seeking cocaine dependent individuals (13F/27M) were randomly assigned to receive either placebo or up to 3mgs of Guanfacine. Three laboratory sessions were conducted following 3-4 weeks of abstinence, w

SUBMITTER: Milivojevic V 

PROVIDER: S-EPMC5599361 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature