Role of molecular turnover in dynamic deformation of a three-dimensional cellular membrane.

ABSTRACT: In cells, the molecular constituents of membranes are dynamically turned over by transportation from one membrane to another. This molecular turnover causes the membrane to shrink or expand by sensing the stress state within the cell, changing its morphology. At present, little is known as to how this turnover regulates the dynamic deformation of cellular membranes. In this study, we propose a new physical model by which molecular turnover is coupled with three-dimensional membrane deformation to explore mechanosensing roles of turnover in cellular membrane deformations. In particular, as an example of microscopic machinery, based on a coarse-graining description, we suppose that molecular turnover depends on the local membrane strain. Using the proposed model, we demonstrate computational

SUBMITTER: Okuda S 

PROVIDER: S-EPMC5599494 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature