Evasion of regulatory phosphorylation by an alternatively spliced isoform of Musashi2.

ABSTRACT: The Musashi family of RNA binding proteins act to promote stem cell self-renewal and oppose cell differentiation predominantly through translational repression of mRNAs encoding pro-differentiation factors and inhibitors of cell cycle progression. During tissue development and repair however, Musashi repressor function must be dynamically regulated to allow cell cycle exit and differentiation. The mechanism by which Musashi repressor function is attenuated has not been fully established. Our prior work indicated that the Musashi1 isoform undergoes site-specific regulatory phosphorylation. Here, we demonstrate that the canonical Musashi2 isoform is subject to similar regulated site-specific phosphorylation, converting Musashi2 from a repressor to an activator of target mRNA translation. We

SUBMITTER: MacNicol MC 

PROVIDER: S-EPMC5599597 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature