Systematic review and meta-analysis of differentially expressed miRNAs in experimental and human temporal lobe epilepsy.

ABSTRACT: Temporal lobe epilepsy (TLE) is a common chronic neurological disease in humans. A number of studies have demonstrated differential expression of miRNAs in the hippocampus of humans with TLE and in animal models of experimental epilepsy. However, the dissimilarities in experimental design have led to largely discordant results across these studies. Thus, a comprehensive comparison is required in order to better characterize miRNA profiles obtained in various post-status epilepticus (SE) models. We therefore created a database and performed a meta-analysis of differentially expressed miRNAs across 3 post-SE models of epileptogenesis (electrical stimulation, pilocarpine and kainic acid) and human TLE with hippocampal sclerosis (TLE-HS). The database includes data from 11 animal post-SE studi

SUBMITTER: Korotkov A 

PROVIDER: S-EPMC5599629 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature