Secretory phospholipase A₂-IIA overexpressing mice exhibit cyclic alopecia mediated through aberrant hair shaft differentiation and impaired wound healing response.

ABSTRACT: Secretory phospholipase A₂ Group-IIA (sPLA₂-IIA) is involved in lipid catabolism and growth promoting activity. sPLA₂-IIA is deregulated in many pathological conditions including various cancers. Here, we have studied the role of sPLA₂-IIA in the development of cyclic alopecia and wound healing response in relation to complete loss of hair follicle stem cells (HFSCs). Our data showed that overexpression of sPLA₂-IIA in homozygous mice results in hyperproliferation and terminal epidermal differentiation followed by hair follicle cycle being halted at anagen like stage. In addition, sPLA₂-IIA induced hyperproliferation leads to compl pathological conditions including various cancers. Here ete exhaustion of hair follicle stem c

SUBMITTER: Chovatiya GL 

PROVIDER: S-EPMC5599634 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature