Gene Expression and Methylation Analyses Suggest DCTD as a Prognostic Factor in Malignant Glioma.

ABSTRACT: Malignant glioma is the most common brain cancer with dismal outcomes. Individual variation of the patients' survival times is remarkable. Here, we investigated the transcriptome and promoter methylation differences between patients of malignant glioma with short (less than one year) and the patients with long (more than three years) survival in CGGA (Chinese Glioma Genome Atlas), and validated the differences in TCGA (The Cancer Genome Atlas) to identify the genes whose expression levels showed high concordance with prognosis of glioma patients, as well as played an important role in malignant progression. The gene coding a key enzyme in genetic material synthesis, dCMP deaminase (DCTD), was found to be significantly correlated with overall survival and high level of DCTD mRNA indicated s

SUBMITTER: Hu H 

PROVIDER: S-EPMC5599690 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature