Histone 3 modifications and blood pressure in the Beijing Truck Driver Air Pollution Study.

ABSTRACT:

Context

Histone modifications regulate gene expression; dysregulation has been linked with cardiovascular diseases. Associations between histone modification levels and blood pressure in humans are unclear.

Objective

We examine the relationship between global histone concentrations and various markers of blood pressure.

Materials and methods

Using the Beijing Truck Driver Air Pollution Study, we investigated global peripheral white blood cell histone modifications (H3K9ac, H3K9me3, H3K27me3, and H3K36me3) associations with pre- and post-work measurements of systolic (SBP) and diastolic (DBP) blood pressure, mean arterial pressure (MAP), and pulse pressure (PP) using multivariable mixed-effect models.

Results

H3K9ac was negatively associated with pre-work SBP an

SUBMITTER: Kresovich JK 

PROVIDER: S-EPMC5599708 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature