Whole-Genome Sequencing and Variant Analysis of Human Papillomavirus 16 Infections.

ABSTRACT: Human papillomavirus (HPV) is a strongly conserved DNA virus, high-risk types of which can cause cervical cancer in persistent infections. The most common type found in HPV-attributable cancer is HPV16, which can be subdivided into four lineages (A to D) with different carcinogenic properties. Studies have shown HPV16 sequence diversity in different geographical areas, but only limited information is available regarding HPV16 diversity within a population, especially at the whole-genome level. We analyzed HPV16 major variant diversity and conservation in persistent infections and performed a single nucleotide polymorphism (SNP) comparison between persistent and clearing infections. Materials were obtained in the Netherlands from a cohort study with longitudinal follow-up for up to 3 years.

SUBMITTER: van der Weele P 

PROVIDER: S-EPMC5599754 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature