Cohesins and condensins orchestrate the 4D dynamics of yeast chromosomes during the cell cycle.

ABSTRACT: Duplication and segregation of chromosomes involves dynamic reorganization of their internal structure by conserved architectural proteins, including the structural maintenance of chromosomes (SMC) complexes cohesin and condensin. Despite active investigation of the roles of these factors, a genome-wide view of dynamic chromosome architecture at both small and large scale during cell division is still missing. Here, we report the first comprehensive 4D analysis of the higher-order organization of the Saccharomyces cerevisiae genome throughout the cell cycle and investigate the roles of SMC complexes in controlling structural transitions. During replication, cohesion establishment promotes numerous long-range intra-chromosomal contacts and correlates with the individualization of chr

SUBMITTER: Lazar-Stefanita L 

PROVIDER: S-EPMC5599795 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature