Hemin binding by Porphyromonas gingivalis strains is dependent on the presence of A-LPS.

ABSTRACT: Porphyromonas gingivalis is a Gram-negative black pigmenting anaerobe that is unable to synthesize heme [Fe(II)-protoporphyrin IX] or hemin [Fe(III)-protoporphyrin IX-Cl], which are important growth/virulence factors, and must therefore derive them from the host. Porphyromonas gingivalis expresses several proteinaceous hemin-binding sites, which are important in the binding/transport of heme/hemin from the host. It also synthesizes several virulence factors, namely cysteine-proteases Arg- and Lys-gingipains and two lipopolysaccharides (LPS), O-LPS and A-LPS. The gingipains are required for the production of the black pigment, μ-oxo-bisheme {[Fe(III)PPIX]₂ O}, which is derived from hemoglobin and deposited on the bacterial cell-surface leading to the characteristic black colonies

SUBMITTER: Rangarajan M 

PROVIDER: S-EPMC5600137 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature