¹⁸ F-fluoromisonidazole uptake in advanced stage non-small cell lung cancer: A voxel-by-voxel PET kinetics study.

ABSTRACT:

Purpose

The aim of this study was to determine the relative abilities of compartment models to describe time-courses of ¹⁸ F-fluoromisonidazole (FMISO) uptake in tumor voxels of patients with non-small cell lung cancer (NSCLC) imaged using dynamic positron emission tomography. Also to use fits of the best-performing model to investigate changes in fitted rate-constants with distance from the tumor edge.

Methods

Reversible and irreversible two- and three-tissue compartment models were fitted to 24 662 individual voxel time activity curves (TACs) obtained from tumors in nine patients, each imaged twice. Descriptions of the TACs provided by the models were compared using the Akaike and Bayesian information criteria (AIC and BIC). Two different models (two- and three-

SUBMITTER: McGowan DR 

PROVIDER: S-EPMC5600259 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature