Serotonergic Modulation of Sensory Representation in a Central Multisensory Circuit Is Pathway Specific.

ABSTRACT: Many studies have explored how neuromodulators affect synaptic function, yet little is known about how they modify computations at the microcircuit level. In the dorsal cochlear nucleus (DCN), a region that integrates auditory and multisensory inputs from two distinct pathways, serotonin (5-HT) enhances excitability of principal cells, predicting a generalized reduction in sensory thresholds. Surprisingly, we found that when looked at from the circuit level, 5-HT enhances signaling only from the multisensory input, while decreasing input from auditory fibers. This effect is only partially explained by an action on auditory nerve terminals. Rather, 5-HT biases processing for one input pathway by simultaneously enhancing excitability in the principal cell and in a pathway-specific feed-forwa

SUBMITTER: Tang ZQ 

PROVIDER: S-EPMC5600294 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature