Longitudinal co-variations between inflammatory cytokines, lung function and patient reported outcomes in patients with asthma.

ABSTRACT:

Background

Asthma is a chronic inflammatory respiratory disorder associated with reduced lung function and poor quality of life. The condition is also associated with poor self-rated health, a major predictor of objective health trajectories. Of biological correlates to self-rated health, evidence suggests a role for inflammatory cytokines and related sickness behaviours. However, this is mainly based on cross-sectional data, and the relation has not been investigated in patients with chronic inflammatory conditions.

Objective

To investigate inflammatory cytokines, lung function, sickness behaviour and asthma-related quality of life as determinants of self-rated health in patients with asthma, and to investigate if these variables co-vary over time.

Methods

Plasma cyt

SUBMITTER: Lodin K 

PROVIDER: S-EPMC5600400 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature