A pilot study of hydroxyurea to prevent chronic organ damage in young children with sickle cell anemia.

ABSTRACT:

Background

Hydroxyurea improves laboratory parameters and prevents acute clinical complications of sickle cell anemia (SCA) in children and adults, but its effects on organ function remain incompletely defined.

Methods

To assess the safety and efficacy of hydroxyurea in young children with SCA and to prospectively assess kidney and brain function, 14 young children (mean age 35 months) received hydroxyurea at a mean maximum tolerated dose (MTD) of 28 mg/kg/day.

Results

After a mean of 25 months, expected laboratory effects included significant increases in hemoglobin, MCV and %HbF along with significant decreases in reticulocytes, absolute neutrophil count, and bilirubin. There was no significant increase in glomerular filtration rate by DTPA clearance or Schwartz est

SUBMITTER: Thornburg CD 

PROVIDER: S-EPMC5600482 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature