Longitudinal Cognitive Outcomes of Clinical Phenotypes of Late-Life Depression.

ABSTRACT:

Objective

Late-life depression is associated with cognitive deficits and increased risk for cognitive decline. The purpose of the study was to determine whether clinical characteristics could serve as phenotypes informative of subsequent cognitive decline. Age at depression onset and antidepressant remission at 3 months (acute response) and 12 months (chronic response) were examined.

Methods

In a longitudinal study of late-life depression in an academic center, 273 depressed and 164 never-depressed community-dwelling elders aged 60 years or older were followed on average for over 5 years. Participants completed annual neuropsychological testing. Neuropsychological measures were converted to z-scores derived from the baseline performance of all participants. Cognitive domain

SUBMITTER: Riddle M 

PROVIDER: S-EPMC5600662 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature