Analysis of Contractility and Invasion Potential of Two Canine Mammary Tumor Cell Lines.

ABSTRACT: Cancer cells are surrounded by a mechanically and biochemically distinct microenvironment that undergoes dynamic changes throughout the neoplastic progression. During this progression, some cancer cells acquire abnormal characteristics that potentiate their escape from the primary tumor site, to establish secondary tumors in distant organs. Recent studies with several human cancer cell lines have shown that the altered physical properties of tumor cells, such as their ability to apply high traction forces to the surroundings, are directly linked with their potential to invade and metastasize. To test the hypothetical interconnection between actomyosin-mediated traction forces and invasion potential within 3D-microenvironment, we utilized two canine mammary tumor cell lines with different c

SUBMITTER: Rajakyla K 

PROVIDER: S-EPMC5600937 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature