Multimodal image analysis of clinical influences on preterm brain development.

ABSTRACT:

Objective

Premature birth is associated with numerous complex abnormalities of white and gray matter and a high incidence of long-term neurocognitive impairment. An integrated understanding of these abnormalities and their association with clinical events is lacking. The aim of this study was to identify specific patterns of abnormal cerebral development and their antenatal and postnatal antecedents.

Methods

In a prospective cohort of 449 infants (226 male), we performed a multivariate and data-driven analysis combining multiple imaging modalities. Using canonical correlation analysis, we sought separable multimodal imaging markers associated with specific clinical and environmental factors and correlated to neurodevelopmental outcome at 2 years.

Results

We found five

SUBMITTER: Ball G 

PROVIDER: S-EPMC5601217 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature