Influence of Age and Eosinophilic Esophagitis on Esophageal Distensibility in a Pediatric Cohort.

ABSTRACT:

Objectives

Sequelae of eosinophilic esophagitis (EoE) include food impaction and esophageal stricture. Duration of inflammation is a predicted risk factor; however, complications remain unpredictable. Studies using the functional lumen imaging probe (FLIP) have demonstrated decreased distensibility of the esophagus in adult patients with EoE. As the impact of inflammation on the developing esophagus is unknown, we investigated esophageal distensibility in a pediatric cohort to determine the effect of age, ongoing inflammation, and fibrotic features on distensibility.

Methods

We conducted a prospective observational study at two tertiary pediatric institutions. Subjects underwent FLIP evaluation during endoscopy to determine distensibility of the esophagus. During stepwise di

SUBMITTER: Menard-Katcher C 

PROVIDER: S-EPMC5601317 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature