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Structure-Affinity Relationships and Structure-Kinetics Relationships of Pyrido[2,1-f]purine-2,4-dione Derivatives as Human Adenosine A₃ Receptor Antagonists.

ABSTRACT: We expanded on a series of pyrido[2,1-f]purine-2,4-dione derivatives as human adenosine A₃ receptor (hA₃R) antagonists to determine their kinetic profiles and affinities. Many compounds showed high affinities and a diverse range of kinetic profiles. We found hA₃R antagonists with very short residence time (RT) at the receptor (2.2 min for 5) and much longer RTs (e.g., 376 min for 27 or 391 min for 31). Two representative antagonists (5 and 27) were tested in [³⁵S]GTPγS binding assays, and their RTs appeared correlated to their (in)surmountable antagonism. From a k_on-k_off-K_D kinetic map, we divided the antagonists into three subgroups, providing a possible direction for the further development of hA₃R an

SUBMITTER: Xia L

PROVIDER: S-EPMC5601358 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Structure-Affinity Relationships and Structure-Kinetics Relationships of Pyrido[2,1-f]purine-2,4-dione Derivatives as Human Adenosine A₃ Receptor Antagonists.

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Structure-Affinity Relationships and Structure-Kinetics Relationships of Pyrido[2,1-f]purine-2,4-dione Derivatives as Human Adenosine A3 Receptor Antagonists.

OmicsDI is part of the ELIXIR infrastructure

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Structure-Affinity Relationships and Structure-Kinetics Relationships of Pyrido[2,1-f]purine-2,4-dione Derivatives as Human Adenosine A₃ Receptor Antagonists.