Human menstrual blood-derived mesenchymal stem cells as a cellular vehicle for malignant glioma gene therapy.

ABSTRACT: Despite many advances in conventional treatment strategies, there is no effective treatment modality for malignant gliomas. Gene therapy may offer a promising option for gliomas and several gene therapy approaches have shown anti-tumor efficiency in previous studies. Mesenchymal stem cell-based gene therapies, in which stem cells are genetically engineered to express therapeutic molecules, have shown tremendous potential because of their innate homing ability. In this study, human menstrual blood-derived MSCs (MenSC), a novel type of multipotential MSCs displays tropism for human malignant glioma when used as a gene delivery vehicle for therapeutics. Secretable trimeric TRAIL (stTRAIL) contains the receptor-binding domain of TRAIL, a death ligand that induces apoptosis in tumor cells. To o

SUBMITTER: Wang XJ 

PROVIDER: S-EPMC5601654 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature