Ontology highlight
ABSTRACT:
SUBMITTER: Hu G
PROVIDER: S-EPMC5601682 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Oncotarget 20170425 35
The long noncoding RNA HOTAIR promotes the development and progression of several tumors. Here, the clinical significance and role of HOTAIR in renal cell carcinoma (RCC) tumorigenesis were explored. The results showed that increased expression of HOTAIR predicted a poor prognosis of RCC after surgery. HOTAIR promoted RCC cell proliferation and growth <i>in vitro</i> and <i>in vivo</i>. The expressions of HOTAIR and Salvador homolog 1 (SAV1) were inversely correlated in clinical RCC samples. HOT ...[more]