Identification of potential cancer-related pseudogenes in lung adenocarcinoma based on ceRNA hypothesis.

ABSTRACT: Pseudogenes are initially regarded as non-functional genomic fossils resulted from inactivating gene mutations during evolution. Far from being silent, pseudogenes are proved to regulate the expression of protein-coding genes through function as microRNA sponge in vivo. The aim of our study was to propose an integrative systems biology approach to identify disease pseudogenes base on competitive endogenous RNA (ceRNA) hypothesis. Here, we applied our method to lung adenocarcinoma (LUAD) RNASeq data from TCGA and identified 33 candidate pseudogenes. We described the characteristics of the candidate pseudogenes and performed functional enrichment. Through analyzing neighboring genes we found these pseudogenes were surrounded by tumor genes and may involve in tumor pathway. Furthermore

SUBMITTER: Wei Y 

PROVIDER: S-EPMC5601712 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature