General anesthesia exposure and risk of dementia: a meta-analysis of epidemiological studies.

ABSTRACT: The association between exposure to general anesthesia and dementia risk has been inconsistently reported across epidemiological studies. To better understand the association, we conducted a meta-analysis of epidemiological studies. PubMed and Embase were searched through April 2017. Random-effects models were used to pool association estimates. We further evaluated potential dose-response relationship. Based on literature search, seven prospective/cohort studies, 11 case-control studies, and a pooled analysis of six case-control studies were identified. Sixteen of these studies were with high quality. After pooling available risk estimates, overall no significant association between exposure to general anesthesia (yes versus no) and dementia risk was detected (odds ratio (OR) = 1.03, 95%

SUBMITTER: Jiang J 

PROVIDER: S-EPMC5601762 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature