LncRNAs as prognostic molecular biomarkers in hepatocellular carcinoma: a systematic review and meta-analysis.

ABSTRACT: The latest studies have shown that long non-coding RNAs (lncRNAs) may be considered markers as their expression levels were abnormal in cancer and can be used as a molecular biomarker for the potential assessment of cancer prognosis. In this study, we aimed to assess the prognostic value of lncRNA as marker of patients with hepatocellular carcinoma. We performed a detailed search of the PubMed and Embase databases for articles on the prognostic value of various lncRNAs in HCC. We then carefully extracted the relevant data from the articles, and we used the meta-analysis method to analyze these results; heterogeneity and publication bias were also evaluated. With 40 associative studies included, we found that high expression of 27 types of lncRNA was associated with a poor prognosis in HCC

SUBMITTER: Zheng C 

PROVIDER: S-EPMC5601763 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature