Metabolites of milk intake: a metabolomic approach in UK twins with findings replicated in two European cohorts.

ABSTRACT:

Purpose

Milk provides a significant source of calcium, protein, vitamins and other minerals to Western populations throughout life. Due to its widespread use, the metabolic and health impact of milk consumption warrants further investigation and biomarkers would aid epidemiological studies.

Methods

Milk intake assessed by a validated food frequency questionnaire was analyzed against fasting blood metabolomic profiles from two metabolomic platforms in females from the TwinsUK cohort (n = 3559). The top metabolites were then replicated in two independent populations (EGCUT, n = 1109 and KORA, n = 1593), and the results from all cohorts were meta-analyzed.

Results

Four metabolites were significantly associated with milk intake in the TwinsUK cohort after adjustment for m

SUBMITTER: Pallister T 

PROVIDER: S-EPMC5602055 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature