Liver Adiposity and Metabolic Profile in Individuals with Chronic Spinal Cord Injury.

ABSTRACT:

Purpose

To quantify liver adiposity using magnetic resonance imaging (MRI) and to determine its association with metabolic profile in men with spinal cord injury (SCI).

Materials and methods

MRI analysis of liver adiposity by fat signal fraction (FSF) and visceral adipose tissue (VAT) was completed on twenty participants. Intravenous glucose tolerance test was conducted to measure glucose effectiveness (S_g) and insulin sensitivity (S_i). Lipid panel, fasting glucose, glycated hemoglobin (HbA1c), and inflammatory cytokines were also analyzed.

Results

Average hepatic FSF was 3.7% ± 2.1. FSF was positively related to TG, non-HDL-C, fasting glucose, HbA1c, VAT, and tumor necrosis factor alpha (TNF-α). FSF was negatively related to

SUBMITTER: Rankin KC 

PROVIDER: S-EPMC5602482 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature