Impact of time-of-day on brain morphometric measures derived from T1-weighted magnetic resonance imaging.

ABSTRACT: Measures of brain morphometry derived from T1-weighted (T1W) magnetic resonance imaging (MRI) are widely used to elucidate the relation between brain structure and function. However, the computation of T1W morphometric measures can be confounded by subject-related factors such as head motion and level of hydration. A recent study reported subtle yet significant changes in brain volume from morning to evening in a large group of patient populations as well as in healthy elderly individuals. In addition, there is a growing recognition that factors such as circadian rhythm can impact MRI measures of brain function and structure. Here, we provide a comprehensive assessment of the impact of time-of-day (TOD) on widely used measures of brain morphometry in a group of 19 healthy young adults. Our

SUBMITTER: Trefler A 

PROVIDER: S-EPMC5602560 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature