Expression and prognosis analyses of the Tob/BTG antiproliferative (APRO) protein family in human cancers.

ABSTRACT:

Background

Despite advances in early diagnosis and treatment, cancer remains the major cause of mortality in the world. The Tob/BTG antiproliferative (APRO) protein family is reported to participate in diverse human diseases. However, there's little known about their expression and prognostic values in most human cancers.

Methods

We performed a detailed cancer vs. normal analysis. The mRNA expression levels of APRO family in various cancers were analyzed via the Oncomine database. Moreover, the Kaplan-Meier Plotter and PrognScan databases were used to evaluate the prognostic values.

Results

We observed that the mRNA expression levels of TOB1-2 and BTG2 were decreased in most cancers compared with normal tissues, while BTG3 was upregulated in most cancers. In survival

SUBMITTER: Bai Y 

PROVIDER: S-EPMC5602628 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature