Impedance biosensor for real-time monitoring and prediction of thrombotic individual profile in flowing blood.

ABSTRACT: A new biosensor for the real-time analysis of thrombus formation is reported. The fast and accurate monitoring of the individual thrombotic risk represents a challenge in cardiovascular diagnostics and in treatment of hemostatic diseases. Thrombus volume, as representative index of the related thrombotic status, is usually estimated with confocal microscope at the end of each in vitro experiment, without providing a useful behavioral information of the biological sample such as platelets adhesion and aggregation in flowing blood. Our device has been developed to work either independently or integrated with the microscopy system; thus, images of the fluorescently labeled platelets are acquired in real-time during the whole blood perfusion, while the global electrical impedance of the blood

SUBMITTER: De Zanet D 

PROVIDER: S-EPMC5602635 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature