Evaluating Which Dose-Function Metrics Are Most Critical for Functional-Guided Radiation Therapy.

ABSTRACT:

Purpose

Four-dimensional (4D) computed tomography (CT) ventilation imaging is increasingly being used to calculate lung ventilation and implement functional-guided radiation therapy in clinical trials. There has been little exhaustive work evaluating which dose-function metrics should be used for treatment planning and plan evaluation. The purpose of our study was to evaluate which dose-function metrics best predict for radiation pneumonitis (RP).

Methods and materials

Seventy lung cancer patients who underwent 4D CT imaging and pneumonitis grading were assessed. Pretreatment 4D CT scans of each patient were used to calculate ventilation images. We evaluated 3 types of dose-function metrics that combined the patient's 4D CT ventilation image and treatment planning dose distr

SUBMITTER: Faught AM 

PROVIDER: S-EPMC5603256 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature