Fetal overnutrition and offspring insulin resistance and β-cell function: the Exploring Perinatal Outcomes among Children (EPOCH) study.

ABSTRACT:

Aims

To examine the associations of intrauterine exposure to maternal diabetes and obesity with offspring insulin resistance, β-cell function and oral disposition index in a longitudinal observational study of ethnically diverse offspring.

Methods

A total of 445 offspring who were exposed (n=81) or not exposed (n=364) to maternal diabetes in utero completed two fasting blood measurements at mean (sd) ages of 10.5 (1.5) and 16.5 (1.2) years, respectively, and an oral glucose tolerance test at the second visit. We used linear mixed models and general linear univariate models to evaluate the associations of maternal diabetes and pre-pregnancy BMI with offspring outcomes.

Results

Maternal diabetes in utero predicted increased insulin resistance [18% higher updated homeost

SUBMITTER: Sauder KA 

PROVIDER: S-EPMC5603388 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature