Effects of Immunoglobulin Replacement on Asthma Exacerbation in Adult Asthmatics with IgG Subclass Deficiency.

ABSTRACT:

Purpose

Recurrent respiratory tract infection is a common manifestation of primary immunodeficiency disease, and respiratory viruses or bacteria are important triggers of asthma exacerbations. Asthma often coexists with humoral immunodeficiency in adults, and some asthmatics with immunoglobulin (Ig) G subclass deficiency (IgGSCD) suffer from recurrent exacerbations. Although some studies suggest a benefit from Ig replacement, others have failed to support its use. This study aimed to assess the effect of Ig replacement on asthma exacerbation caused by respiratory infection as well as the asthma control status of adult asthmatics with IgGSCD.

Methods

This is a multi-center, open-label study of adult asthmatics with IgGSCD. All patients received monthly intravenous immunoglobu

SUBMITTER: Kim JH 

PROVIDER: S-EPMC5603481 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature