Adrenergic Stress Protection of Human iPS Cell-Derived Cardiomyocytes by Fast K_v7.1 Recycling.

ABSTRACT: The fight-or-flight response (FFR), a physiological acute stress reaction, involves positive chronotropic and inotropic effects on heart muscle cells mediated through β-adrenoceptor activation. Increased systolic calcium is required to enable stronger heart contractions whereas elevated potassium currents are to limit the duration of the action potentials and prevent arrhythmia. The latter effect is accomplished by an increased functional activity of the K_v7.1 channel encoded by KCNQ1. Current knowledge, however, does not sufficiently explain the full extent of rapid K_v7.1 activation and may hence be incomplete. Using inducible genetic KCNQ1 complementation in KCNQ1-deficient human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs),

SUBMITTER: Piccini I 

PROVIDER: S-EPMC5603700 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature