The Role of microRNA Expression in Cortical Development During Conversion to Psychosis.

ABSTRACT: In a recent report of the North American Prodrome Longitudinal Study (NAPLS), clinical high-risk individuals who converted to psychosis showed a steeper rate of cortical gray matter reduction compared with non-converters and healthy controls, and the rate of cortical thinning was correlated with levels of proinflammatory cytokines at baseline. These findings suggest a critical role for microglia, the resident macrophages in the brain, in perturbations of cortical maturation processes associated with onset of psychosis. Elucidating gene expression pathways promoting microglial action prior to disease onset would inform potential preventative intervention targets. Here we used a forward stepwise regression algorithm to build a classifier of baseline microRNA expression in peripheral leukocyt

SUBMITTER: Zheutlin AB 

PROVIDER: S-EPMC5603810 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature