Presynaptic Dopamine Synthesis Capacity in Schizophrenia and Striatal Blood Flow Change During Antipsychotic Treatment and Medication-Free Conditions.

ABSTRACT: Standard-of-care biological treatment of schizophrenia remains dependent upon antipsychotic medications, which demonstrate D₂ receptor affinity and elicit variable, partial clinical responses via neural mechanisms that are not entirely understood. In the striatum, where D₂ receptors are abundant, antipsychotic medications may affect neural function in studies of animals, healthy volunteers, and patients, yet the relevance of this to pharmacotherapeutic actions remains unresolved. In this same brain region, some individuals with schizophrenia may demonstrate phenotypes consistent with exaggerated dopaminergic signaling, including alterations in dopamine synthesis capacity; however, the hypothesis that dopamine system characteristics underlie variance in medication-indu

SUBMITTER: Eisenberg DP 

PROVIDER: S-EPMC5603816 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature