5-hydroxymethylcytosine is highly dynamic across human fetal brain development.

ABSTRACT:

Background

Epigenetic processes play a key role in orchestrating transcriptional regulation during the development of the human central nervous system. We previously described dynamic changes in DNA methylation (5mC) occurring during human fetal brain development, but other epigenetic processes operating during this period have not been extensively explored. Of particular interest is DNA hydroxymethylation (5hmC), a modification that is enriched in the human brain and hypothesized to play an important role in neuronal function, learning and memory. In this study, we quantify 5hmC across the genome of 71 human fetal brain samples spanning 23 to 184 days post-conception.

Results

We identify widespread changes in 5hmC occurring during human brain development, notable sex-differ

SUBMITTER: Spiers H 

PROVIDER: S-EPMC5604137 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature