Villi-specific Gene Expression Reveals Novel Prognostic Biomarkers in Multiple Human Cancers.

ABSTRACT: Despite many striking connections, the biological similarities between embryonic development and tumorigenesis have not been well explored. Development of the placental villi is a crucial process involving many cellular activities, including immunity, proliferation, and cell adhesion. In this study, we designed a strategy to identify the gene expression pattern of villi development and to explore the corresponding features in tumors. We discovered villi-specific genes that are highly expressed in the villus as opposed to the mature placenta and then measured the expression levels of these genes in tumors. We found large changes in the expression of villi-specific genes in multiple types of cancer. These villi-specific genes showed distinct expression patterns and were primarily involved in

SUBMITTER: Zhang B 

PROVIDER: S-EPMC5604211 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature