Osteoglycin promotes meningioma development through downregulation of NF2 and activation of mTOR signaling.

ABSTRACT:

Background

Meningiomas are the most common primary intracranial tumors in adults. While a majority of meningiomas are slow growing neoplasms that may cured by surgical resection, a subset demonstrates more aggressive behavior and insidiously recurs despite surgery and radiation, without effective alternative treatment options. Elucidation of critical mitogenic pathways in meningioma oncogenesis may offer new therapeutic strategies. We performed an integrated genomic and molecular analysis to characterize the expression and function of osteoglycin (OGN) in meningiomas and explored possible therapeutic approaches for OGN-expressing meningiomas.

Methods

OGN mRNA expression in human meningiomas was assessed by RNA microarray and RNAscope. The impact of OGN on cell proliferation,

SUBMITTER: Mei Y 

PROVIDER: S-EPMC5604305 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature