A Prospective Investigation of Coffee Drinking and Bladder Cancer Incidence in the United States.

ABSTRACT:

Background

In 1991, coffee was classified as a group 2B carcinogen, possibly carcinogenic to humans, based on limited epidemiologic evidence of a positive association with bladder cancer. In 2016, the International Agency for Research on Cancer downgraded this classification due to lack of evidence from prospective studies particularly for never smokers.

Methods

Baseline coffee drinking was assessed with a food frequency questionnaire in the NIH-AARP prospective cohort study. Among 469,047 US adults, who were cancer free at baseline, 6,012 bladder cancer cases (5,088 men and 924 women) were identified during >6.3 million person-years of follow-up. Multivariable-adjusted Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI)

SUBMITTER: Loftfield E 

PROVIDER: S-EPMC5604321 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature