Longitudinal Outcomes of Patients With Single Ventricle After the Fontan Procedure.

ABSTRACT:

Background

Multicenter longitudinal objective data for survival into adulthood of patients who have undergone Fontan procedures are lacking.

Objectives

This study sought to describe transplant-free survival and explore relationships between laboratory measures of ventricular performance and functional status over time.

Methods

Exercise testing, echocardiography, B-type natriuretic peptide, functional health assessment, and medical history abstraction were repeated 9.4 ± 0.4 years after the Fontan Cross-Sectional Study (Fontan 1) and compared with previous values. Cox regression analysis explored risk factors for interim death or cardiac transplantation.

Results

From the original cohort of 546 subjects, 466 were contacted again, and 373 (80%) were enrolled at 21

SUBMITTER: Atz AM 

PROVIDER: S-EPMC5604334 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature