Hyperpolarized ¹³C Diffusion MRS of Co-Polarized Pyruvate and Fumarate to Measure Lactate Export and Necrosis.

ABSTRACT: Background: Non-invasive tumor characterization and monitoring are among the key goals of medical imaging. Using hyperpolarized ¹³C-labelled metabolic probes fast metabolic pathways can be probed in real-time, providing new opportunities for tumor characterization. In this in vitro study, we investigated whether measurement of apparent diffusion coefficient (ADC) measurements and magnetic resonance spectroscopy (MRS) of co-polarized ¹³C-labeled pyruvic acid and fumaric acid can non-invasively detect both necrosis and changes in lactate export, which are parameters indicative of tumor aggressiveness. Methods:¹³C-labeled pyruvic acid and fumaric acid were co-polarized in a preclinical hyperpolarizer and the dissolved compounds were added

SUBMITTER: Feuerecker B 

PROVIDER: S-EPMC5604459 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature