Age-related changes in structural connectivity are improved using subject-specific thresholding.

ABSTRACT:

Background

Deterministic diffusion tractography obtained from high angular resolution diffusion imaging (HARDI) requires user-defined quantitative anisotropy (QA) thresholds. Most studies employ a common threshold across all subjects even though there is a strong degree of individual variation within groups. We sought to explore whether it would be beneficial to use individual thresholds in order to accommodate individual variance. To do this, we conducted two independent experiments.

Method

First, tractography of the arcuate fasciculus and network connectivity measures were examined in a sample of 14 healthy participants. Second, we assessed the effects of QA threshold on group differences in network connectivity measures between healthy young (n=19) and old (n=14) individu

SUBMITTER: Bauer CM 

PROVIDER: S-EPMC5604482 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature