The outcome of prostate cancer patients treated with curative intent strongly depends on survival after metastatic progression.

ABSTRACT:

Background

Five-year survival in patients with localized prostate cancer (PCa) is nearly 100%, but metastatic disease still remains incurable. Clinical management of metastatic patients has become increasingly complex as novel therapeutic strategies have emerged. This study aims at evaluating the impact of the first metastatic progression on the outcome of PCa patients treated with curative intent.

Methods

The analysis was conducted using data of 913 cases of localized PCa diagnosed between 2000 and 2014. All patients were treated with curative surgery (N = 382) or radiotherapy (N = 531) with or without adjuvant therapy. All metastases were radiologically documented. The prognostic impact of the first site of metastasis on metastasis-free survival (MFS) and PCa-specific surv

SUBMITTER: Pascale M 

PROVIDER: S-EPMC5604496 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature