Whole blood gene expression and white matter Hyperintensities.

ABSTRACT:

Background

White matter hyperintensities (WMH) are an important biomarker of cumulative vascular brain injury and have been associated with cognitive decline and an increased risk of dementia, stroke, depression, and gait impairments. The pathogenesis of white matter lesions however, remains uncertain. The characterization of gene expression profiles associated with WMH might help uncover molecular mechanisms underlying WMH.

Methods

We performed a transcriptome-wide association study of gene expression profiles with WMH in 3248 participants from the Framingham Heart Study using the Affymetrix Human Exon 1.0 ST Array.

Results

We identified 13 genes that were significantly associated with WMH (FDR < 0.05) after adjusting for age, sex and blood cell components. Many of t

SUBMITTER: Lin H 

PROVIDER: S-EPMC5604498 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature