Pragmatic clinical trials embedded in healthcare systems: generalizable lessons from the NIH Collaboratory.

ABSTRACT:

Background

The clinical research enterprise is not producing the evidence decision makers arguably need in a timely and cost effective manner; research currently involves the use of labor-intensive parallel systems that are separate from clinical care. The emergence of pragmatic clinical trials (PCTs) poses a possible solution: these large-scale trials are embedded within routine clinical care and often involve cluster randomization of hospitals, clinics, primary care providers, etc. Interventions can be implemented by health system personnel through usual communication channels and quality improvement infrastructure, and data collected as part of routine clinical care. However, experience with these trials is nascent and best practices regarding design operational, analytic, and r

SUBMITTER: Weinfurt KP 

PROVIDER: S-EPMC5604499 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature