Peak nasal inspiratory flow as outcome for provocation studies in allergen exposure chambers: a GA²LEN study.

ABSTRACT:

Background

The GA²LEN chamber has been developed as a novel mobile allergen exposure chamber (AEC) allowing standardized multicenter trials in allergy. Hitherto, subjective nasal symptom scores have been the most often used outcome parameter, but in standardized modern trials objective parameters are preferred. Despite its practicability, the objective parameter peak nasal inspiratory flow (PNIF) has been rarely used for allergy trials in the setting of allergen exposure chambers. This study aims to evaluate PNIF as an outcome parameter for provocation studies in AECs.

Methods

In a randomized controlled blinded setting subjects suffering from allergic rhinitis were exposed to grass pollen, birch pollen, house dust mite and/or placebo in the GA²LEN chamb

SUBMITTER: Boelke G 

PROVIDER: S-EPMC5604509 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature