A meta-analysis of the preoperative use of gabapentinoids for the treatment of acute postoperative pain following spinal surgery.

ABSTRACT:

Background

Gabapentinoid drugs, which include gabapentin and pregabalin, play an established role in the management of neuropathic pain. However, whether preoperative administration of gabapentinoids has a beneficial role in controlling acute pain after spinal surgery is unknown. We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) to determine the efficacy and safety of the preoperative use of gabapentinoids (gabapentin and pregabalin) for the treatment of acute postoperative pain following spinal surgery.

Methods

In March 2017, a systematic computer-based search was conducted in PubMed, EMBASE, Web of Science, Cochrane Library, and Google databases. RCTs comparing gabapentinoids (gabapentin and pregabalin) with placebo in patients under

SUBMITTER: Liu B 

PROVIDER: S-EPMC5604660 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature